Melatonin supplement study links long-term use with heart failure risk

Study Links Long-Term Melatonin Use to Heart Failure Risk

A recent study analyzed medical records of over 130,000 adults with chronic insomnia who took melatonin supplements for a year or longer. The research suggests a potential connection between prolonged melatonin use and an increased risk of heart failure.

Key Findings from the Study

“The association between melatonin and increased risk of heart failure or death found in this study, which cannot prove a cause-and-effect relationship, raises safety concerns about the use of melatonin, which is widely available, and may warrant more research on melatonin to assess its cardiovascular safety, researchers said.” – American Heart Association

About Melatonin

The Cleveland Clinic explains that melatonin is a natural hormone primarily produced by the pineal gland in the brain. It plays a key role in regulating the sleep-wake cycle and circadian rhythm.

“Melatonin is a natural hormone that’s mainly produced by your pineal gland in your brain.”

However, the Clinic cautions that melatonin supplements are not regulated by the Food and Drug Administration. They emphasize that melatonin is not a “magic pill” for resolving sleep issues.

Author's Summary

While melatonin helps regulate sleep, its long-term use might increase heart failure risk, highlighting the need for caution and further cardiovascular safety research.

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WFTV WFTV — 2025-11-07

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