Think Melatonin Is Safe? New Research Reveals a Hidden Heart Risk
Using melatonin regularly for sleep issues may bring unexpected risks for heart health. A new study suggests that people who rely on melatonin long term face significantly higher odds of hospitalization and death related to heart failure.
Long-Term Use and Its Risks
Researchers discovered that chronic users of melatonin were nearly twice as likely to die and 3.5 times more likely to be hospitalized for heart failure compared to non-users. The findings challenge the common belief that melatonin is harmless when taken for extended periods.
Long-term melatonin use for sleep problems may come with unexpected heart dangers.
Study Details
The preliminary study, presented at the American Heart Association's Scientific Sessions 2025, analyzed adults with long-term insomnia who had taken melatonin for at least one year. These individuals showed a greater likelihood of developing heart failure and higher mortality rates than those not taking the supplement.
The results will be discussed at the AHA's annual meeting, held November 7–10 in New Orleans, an international event dedicated to cardiovascular science and clinical research updates.
What Melatonin Does
Melatonin is a hormone secreted by the pineal gland that helps regulate the body’s sleep-wake rhythm. Its production increases at night and decreases during daylight. Synthetic melatonin, identical to the natural hormone, is commonly used to address insomnia and jet lag.
Availability and Regulation
In countries such as the United States, melatonin supplements are available without prescription. However, because these products are not strictly regulated, their purity and dosage can vary significantly between brands.
Expert Opinion
Specialists now advise caution when using melatonin for extended periods, stressing the need for further research and medical guidance before long-term use.
Author’s summary: New evidence suggests that prolonged melatonin use, while popular for sleep aid, may quietly elevate the risk of heart failure and mortality.