NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, published on October 12, 2025.
Week 6 Predictions
Last week's NFL bold predictions went 2-1, resulting in a total of +1.17 units. Since Week 3, the picks in this story are up 2.16 units.
This Week's Bets
- Fading the Colts offense, despite their strong performance, averaging 3.39 points per drive, which would be the highest this century if maintained.
It’s time for Week 6 of the NFL season.
Author's summary: NFL Week 6 predictions and picks.
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