Key Nervous System Components Influence Gastrointestinal Tumour Growth
Researchers have found that common nervous system components, present in the gastrointestinal tract, influence tumour growth, revealing new opportunities for cancer treatment.
Our gut has its own nervous system, often referred to as the "second brain". Neuropeptides, signalling factors produced and released by nerves, play a key role in the system.
- Neuropeptides relay messages throughout the nervous system by connecting to receptors on the outside of cells.
- They influence various processes, including tumour growth in gastrointestinal cancers.
A team at the Olivia Newton-John Cancer Research Institute (ONJCRI) and La Trobe School of Cancer Medicine discovered that CGRP, a common neuropeptide, and its receptor RAMP1 drive tumour growth in colorectal and stomach cancers.
The gut's nervous system is a key player in tumour growth, creating new avenues for treatment with existing approved therapies.
Author's summary: New research reveals nervous system components influence gastrointestinal tumour growth.
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