New research indicates that individuals with insomnia who take melatonin supplements for over a year may face an increased risk of heart failure compared to those who do not use this common sleep aid.
The study revealed that long-term melatonin users were more likely to be diagnosed with heart failure, require hospitalization for this condition, or die from any cause. These findings were presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans.
“Melatonin supplements may not be as harmless as commonly assumed.”
This preliminary study has not yet been published in a peer-reviewed journal. Researchers emphasize that it does not prove a cause-and-effect relationship between melatonin use and heart failure risk but raises important safety concerns.
Further research is necessary to evaluate the cardiovascular safety of long-term melatonin supplementation.